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Eventually, some patients may taper off medication under medical guidance, while others continue long-term maintenance depending on individual progress

Only 4-7% of participants in SURMOUNT-1 and 2 discontinued the medication due to AE (Tables 2, 3)

Gastrointestinal effects and referred pain: The pronounced gastrointestinal side effects of GLP-1 therapyparticularly nausea, constipation, and abdominal distensioncan occasionally manifest as referred pain to the back