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Abbreviations 14-3-3 : 14-3-3 theta 24hUTP 24-hour : hour urinary total protein 8-oxoG : Oxoguanine ABC ATP: binding cassette AD : Alzheimers disease ADMA : asymmetric dimethylarginine AdipoR1 : adiponectin receptor 1 AGE/RAGE : advanced glycation end products/receptor for advanced glycation end products AGEs : advanced glycation end products AKAP12 : A-kinase anchoring protein 12 Akt : protein kinase B, AKT Protein Kinase B AMPK : AMP-activated protein kinase ANP : atrial natriuretic peptide APAP : acetaminophen APAF1: Apoptotic Protease Activating Factor 1 ARAF6 : ADP-ribosylation factor 6 AREs : antioxidant response elements ASC : apoptosis-associated speck-like protein containing a CARD ATF-2 : Times New Roman ATM: ataxia-telangiectasia-mutated ATP: adenosine triphosphate ATP6V0d1 : ATPase H+ transporting V0 subunit d1 A : amyloid -SMA : -smooth muscle actin BA : bronchial asthma Bax : BCL2-associated X protein Bcl-2 : B-cell lymphoma 2 Bcl-xL : B-cell lymphoma-extra large BCR : B-cell receptor BLNK : B-Cell Linker Protein BNP : brain natriuretic peptide BZBS : Bazi Bushen Formula CCL3 : C-C motif chemokine ligand 3 CCND1 : cyclin D1 CR7 : C-C Motif Chemokine Receptor 7 CD163 : cluster of differentiation 163 CD28 : cluster of differentiation 28 negative CD4 : cluster of differentiation 4 positive CD8 : cluster of differentiation 8 positive CDK : cyclin-dependent kinase CDK4 : cyclin-dependent kinase 4 CDKIs : cyclin-dependent kinase inhibitors CDKN1A : cyclin-dependent kinase inhibitor 1A Cdk1 : cyclin-dependent kinase 1 CHOP: C/EBP homologous protein CK: creatine kinase CK-MB: creatine kinase-MB CLD: chronic liver disease COL-I: collagen type I COL1A1: collagen type I alpha 1 chain COPD: chronic obstructive pulmonary disease CPT1: carnitine palmitoyltransferase 1 CREB: cAMP response element-binding protein CRDs: chronic respiratory diseases CAT: catalase CCl 4 : carbon tetrachloride cAMP: cyclic adenosine monophosphate cGAS-STING: cyclic GMP-AMP synthase-stimulator of interferon genes COVID-19: coronavirus disease 2019 COX-2: cyclooxygenase-2 CVD: cardiovascular disease CYP2E1: cytochrome P450 2E1 DAG: diacylglycerol DAMPs: damage-associated molecular patterns DAT-1: dopamine transporter-1 DCs: dendritic cells DDAH1: dimethylarginine dimethylaminohydrolase 1 DHEA: dehydroepiandrosterone DHEAS: dehydroepiandrosterone sulfate DILI: drug-induced liver injury DN: diabetic nephropathy ECM: extracellular matrix EF%: ejection fraction EMT: epithelialmesenchymal transition eNOS: endothelial nitric oxide synthase ER: endoplasmic reticulum ERK: extracellular signal-regulated kinase EFSA: European Food Safety Authority FAO: fatty acid oxidation FEV50: 50% forced expiratory volume FFA: free fatty acid FTH1: ferritin heavy chain 1 FVC: forced vital capacity FXR: farnesoid X receptor FZD6: frizzled class receptor 6 FS%: fractional shortening GBD: Global Burden of Disease GABA: -aminobutyric acid Glu: glutamate GLP-1: glucagon-like peptide-1 GLUT4: glucose transporter 4 Gomisin A: gomisin A GPCR: protein-coupled receptors GPx: glutathione peroxidase GPR81: G protein-coupled receptor 81 GR: glutathione reductase Gra B: granzyme B GSH: glutathione GSH-Px: glutathione peroxidase GPX4: glutathione peroxidase 4 GSDMD: gasdermin-D GSDMD-N: gasdermin D N-terminus HBsAg: hepatitis B surface antigen HBeAg: hepatitis B e antigen HBV DNA: hepatitis B virus DNA HO-1: heme oxygenase-1 HMOX1: heme oxygenase 1 HPLC: high-performance liquid chromatography HSC: hepatic stellate cell HCC: hepatocellular carcinoma HFD: high-fat diet HIF-1: hypoxia-inducible factor 1 HMGB1: high mobility group box-1 protein HPV: human papillomavirus HW/BW: heart weight/body weight ratio Hyp: hydroxyproline I/R: ischemia/reperfusion IFN-: interferon- IFN: , interferon IKK: IB kinase IKK: inhibitor of nuclear factor kappa-B kinase subunit beta IL-1: interleukin-1 IL-1: interleukin-1 IL-4: interleukin-4 ISGs: interferon-stimulated genes ITAM: immunoreceptor tyrosine-based activation motif ITGA1: integrin subunit alpha 1 TGB4: integrin subunit beta 1 IRS-1: insulin receptor substrate-1 ISO: soproterenol JAK1: Janus kinase 1 JAK1/3: Janus kinase 1/3 JNK: c-Jun N-terminal kinase KYNA: kynurenic acid LCA: lithocholic acid LCN: lipocalin LDL: low-density lipoprotein LDL-C: low-density lipoprotein cholesterol LDH: lactate dehydrogenase LM: lifestyle medicine Lrrk2: leucine-rich repeat kinase 2 LPS: lipopolysaccharide MAPKs: mitogen-activated protein kinases MCP-6: monocyte chemoattractant protein-6 MDA: malondialdehyde MDM2: mouse double minute 2 homolog MDR: multidrug resistance MEK: mitogen-activated protein MHC: MHC class gene MMP: matrix metalloproteinase mPTPs: mitochondrial permeability transition pores MyD88: myeloid differentiation primary response protein 88 mTOR: mammalian target of rapamycin mTORC1/2: mechanistic target of rapamycin complex 1/2 M1: macrophages 1 M2: macrophages 2 NADK: nicotinamide adenine dinucleotide kinase NASH: nonalcoholic steatohepatitis NCDs: non-communicable diseases NDDs: neurodegenerative diseases NFAT: nuclear factors of activated T cells NFTs: neurofibrillary tangles NF-B: nuclear factor-B NF-B p65: nuclear factor B p65 subunit NK: natural killer NLCs: nanostructured lipid carriers NLRP3: NOD-like receptor pyrin domain-containing 3 NLRs: NOD-like receptors NOS3: nitric oxide synthase 3 NO: nitric oxide NOX2: NADPH oxidase 2 NQO1: quinone oxidoreductase 1 Nrf2: nuclear factor erythroid 2-related factor 2 Nrf2/ARE: nuclear factor erythroid 2-related factor 2/antioxidant response element p-Akt: phosphorylated Akt p-EGFR: phosphorylated epidermal growth factor receptor p-ERK: phosphorylated extracellular signal-regulated kinase p-IB: phosphorylated inhibitory kappa B p-JNK: phosphorylated c-Jun N-terminal kinase p-p38: phosphorylated p38 mitogen-activated protein kinase p-Rb: phosphorylated retinoblastoma protein p-TAK1: phosphorylated transforming growth factor--activated kinase 1 p-eNOS: phosphorylated endothelial nitric oxide synthase p53: tumor protein p53 PCNA: proliferating cell nuclear antigen PD: Parkinsons disease PDK1: pyruvate dehydrogenase kinase 1 PI3K: phosphatidylinositol 3-kinase PKA: protein kinase A PLC2: phosphatidylinositol-specific phospholipase C2 PPAR: peroxisome proliferator-activated recep PGC-1: peroxisome proliferator-activated receptor gamma coactivator 1-alpha PPPM/3PM: predictive, preventive, and personalized medicine Ptgs2: prostaglandin-endoperoxide synthase 2 P-gp: P-glycoprotein PTEN: phosphatase and tensin homolog p21: cyclin-dependent kinase inhibitor 1A p27: cyclin-dependent kinase inhibitor 1B ROS: reactive oxygen species RTK: receptor tyrosine kinase S1PR2: sphingosine-1-phosphate receptor 2 SAL: schisanhenol SC: Schisandra chinensis SCFA: short-chain fatty acid SCFAs: short-chain fatty acids SCP: Schisandra chinensis polysaccharide SLE: Schisandra lignan extract Sch A: schisandrin A Sch B: schisandrin B Sch C: Schisandrin C Sin A: schisantherin A SIRT1: irtuin 1 SLC7A11: solute carrier family 7 member 11 SNG-1: synaptogyrin-1 SLNs: solid lipid nanoparticles SOD: superoxide dismutase Sol A: schisandrol A Sol B: schisandrol B SASP: senescence-associated secretory phenotype SPEP: Schisandra chinensis petroleum ether fraction SREBP1/2: sterol regulatory element-binding protein 1/2 STAT3: signal transducer and activator of transcription 3 STING-TBK1: stimulator of interferon genes-TANK-binding kinase 1 TAGLN: transgelin TAK1: transforming growth factor--activated kinase 1 TC: total cholesterol TCH: total cholesterol TCM: traditional Chinese medicine TCR: T-cell receptor TG: riglycerides TGF-: transforming growth factor- TGM2: transglutaminase 2 TRs: TGF- receptors TLR: Toll-like receptor TMA: trimethylamine TMAO: trimethylamine N-oxide TNF-: tumor necrosis factor- Trx-1: thioredoxin-1 TRPM5: transient receptor potential cation channel subfamily M member 5 TXNIP: thioredoxin-interacting protein T1R2: taste receptor type 1 member 2 T2DM: type 2 diabetes mellitus UC-MSCs: umbilical cord-derived mesenchymal stem cells UPR: unfolded protein response UVB: ultraviolet B VAV: proteins are guanine nucleotide exchange factors for Rho family GTPasesZO-1 Zonula occludens-1 VEGFA: vascular endothelial growth factor A VEGFR: vascular endothelial growth factor receptor V-ATPase: vacuolar-type adenosine triphosphatase WHO: World Health Organization -MyHC: -myosin heavy chain -MHC: -myosin heavy chain

The physiology of glucagonlike peptide 1