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Eli Lillys Phase 3 TRIUMPH-4 trial (December 2025) reported that participants taking 12mg of Retatrutide over 68 weeks lost an average of 28.7% of their body weight, the highest result ever reported at that stage for any obesity-related compound

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A new study in Cell Metabolism has shown that Semaglutide the GLP1 behind Ozempic and Wegovy may protect and even regenerate joint cartilage through a mechanism unrelated to weight loss