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Loss or damage to the ICCs appears to be a dominant abnormality [3, 6, 11], where altered immune function with a shift from M2 to M1 macrophage expression and impaired regulation of haem oxygenase 1 leading to increased oxidative stress may be responsible [6, 11]
Diet composition appeared to account for several of the observed microbiome differences
Side Effects and Tolerability GLP-1 medications are generally well-tolerated, with the most common side effects being gastrointestinal issues such as nausea and vomiting
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