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These factors collectively drive the progressive damage of biliary epithelial cells by autoantibodies, leading to cholestasis, fibrosis, and potential progression to cirrhosis or liver failure (217)

Management of Overdosage Following overdose with oral benzodiazepines, general supportive measures should be employed including the monitoring of respiration, pulse, and blood pressure

The treatment continued for 3.5 years (182 weeks), and the study was completed by 260 of the patients

The role of natalizumab in cancer is currently being evaluated in clinical trials in pulmonary metastatic osteosarcoma (NCT03811886), and has previously been evaluated in multiple myeloma (NCT00675428) and acute-graft-vs-host disease (NCT02133924, NCT02176031)