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However, bottlenecks such as immunosenescence and target heterogeneity still need to be overcome

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Unexpectedly, tumor burden was significantly reduced in mice with NOS2-deficient bone marrow chimers compared to the wild-type mice, suggesting that even though the number of M2 macrophages in iNOS-deficient TME is not affected, the immunosuppressive function of M2 macrophages may change