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Human trials of IGF-1 in PD have not yet been performed, but studies in rat models of PD indicate that it protects dopaminergic neurons and improves behavior

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3.2 Pharmacological management of osteoarthritis 3.2.1 Non-opioid analgesics, anti-inflammatory agents, and senescence/ferroptosis-targeted drugs Non-opioid analgesics, particularly non-steroidal anti-inflammatory drugs (NSAIDs), are the pharmacological mainstay for symptom control in OA, particularly in cases presenting with moderate to severe pain (Table 2)

Their wide-ranging applications in disease prevention and treatment underscore their medical significance (65)