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In non-CF bronchiectasis, NAC may reduce exacerbations in frequent exacerbators

In particular, our study showed that the intracellular depletion of GSH is able to induce cellular stress in NO-producing cells through a NO-dependent mechanism, such as inhibition of CcOX activity, DNA damage, and S-NO and 3-nitrotyrosine (NO 2 -Tyr) protein accumulation ( Figure 1 )

The Old Friends hypothesis (Rook, 2007) describes the requirement for early exposure to organisms like STHs, microbes, and environmental factors to prime essential immune development during childhood and ensure the optimal balance between effector and regulatory arms of the immune system