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In this context, breakthrough research and innovative strategies should be used to develop therapies for astrocyte-mediated neurodegeneration by modulating different levels of astrocyte reactivity

Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status

The balloon is connected to an external controller that can be attached to the skin and contains a pump that inflates and deflates the balloon when needed

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