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Key results at the highest dose (24 mg): 22.5% placebo-adjusted mean weight loss at 48 weeks 96% achieved at least 5% weight loss 87% achieved at least 10% weight loss 48% achieved at least 20% weight loss 26% achieved at least 30% weight loss 54% reduced BMI below the obesity threshold (30 kg/m2) versus 13% placebo No weight loss plateau at 48 weeks Discontinuation due to adverse events: 5.9% (CT-388) vs 1.3% (placebo) Preclinical Data# CT-388 improved glycemic control in mice and monkeys, reduced body weight, suppressed appetite, and improved metabolic dysfunction-associated steatohepatitis (MASH) pathology in mice

Semaglutide can be used safely in patients with diverticulitis history when prescribed by a knowledgeable provider and combined with careful dietary management

It is important to notice that the skin of the hand disposes a unique structure and is highly specialized allowing mobility for complex motor skills along with fine sensibility and resistance to withstand tearing and wearing forces

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