glp-1 vs glp Understanding receptor agonists and their impact on drug discovery GLP-1 and GLP-2 Orchestrate Intestine

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A., Li, D., Messerschmidt, M., Boutet, S., Williams, G

A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals

More specifically, an in vivo study, based on chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition, found that lixisenatide significantly upregulated expression of the neurotrophic tyrosine kinase receptor type 2 ( NTRK2 ) gene and of the mammalian target of rapamycin ( mTOR ) gene in the hippocampus, which are involved in regulating synaptic plasticity [100]