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However, skeletal muscle-specific carnitine palmitoyltransferase 2 (CPT2)-deficient mice accumulate large amounts of acylcarnitine in muscle and plasma and still preserve insulin sensitivity [75], highlighting the role of acylcarnitine only as an indicator of FAO rather than as a direct mediator of insulin resistance [76]

Research has investigated its role in sleep-wake cycle regulation, pituitary hormone secretion, stress adaptation, and nociceptive pathways

It also indicates that hypomagnesemia may occur within 1 year of PPI therapy initiation and can have serious clinical consequences[227] At present the mechanism of the PPI-induced low magnesium levels is not known

PMID: 33051481