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Genetic knockout of solute carrier 22A member 4 (SLC22A4), part of the large solute carrier 22A (SLC22A) family, in both mice (25) and zebrafish (26) , resulted in dramatic reduction of ergothioneine to undetectable concentrations in many tissues (e.g

The accumulation of senescent cells in different organs is a precursor of fibrosis development, neurological disorders, or chronic diseases and the rational to develop specific therapies targeting senescent cells has emerged as a promising therapeutic way 2,3,4

May 17, 2009

The samples were diluted in RIPA, mixed with Laemmli buffer (Bio-Rad, Hercules, CA), and then denatured at 95C for 5 min