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cytokines are involved in the development of depressive symptoms, and environmental factors may also trigger both depression and immune disorders (127129)

Clinical therapy of targeting ferroptosis in human diseases Numerous preclinical studies have demonstrated that iron acts as a potent pro-oxidant, contributing to the development and progression of tumors, central nervous system diseases, metabolic diseases, autoimmune diseases, and cardiovascular diseases through the production of highly reactive and cytotoxic free radicals

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Furthermore, these extracellular, normally nuclear proteins impair erythrocyte deformability and increase the adhesive properties of the cells