One such quinone containing compound, doxorubicin, is an anthracycline drug used to treat a variety of human cancers and is regarded as one of the most important chemotherapeutic agents 8
Bivamelagon Bivamelagon (formerly LB54640) is an oral MC4R-selective small molecule agonist as shown in Figure 2 , with nanomolar potency on hMC1R (EC 50 = 84.82 nM) and hMC3R (EC 50 = 130 nM) and low nanomolar potency on hMC4R (EC 50 = 0.98-16.28 nM) ( Table 1 ) (98)
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Endogenous ligands of TSPO, cholesterol and porphyrins, have been reported to regulate neuroplasticity and exhibit antidepressant and anxiolytic effects in animals and humans (Lejri et al., 2019