For the treatment of the atheroscleosis, statins are commonly used due to their excellent efficacy in minimizing the LDL level in the serum and inhibiting the vascular risk, but the continuous use of statins lead to more side effects viz., rhabdomyolysis, myopathy, liver injury, muscle toxicity and acute renal failure (Hopewell, Reith, & Armitage, 2014
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Trumbeckaite S, Opalka JR, Neuhof C, Zierz S, Gellerich FN: Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function
Because the goal is local gut exposure, the oral route is most often selected specifically when the gut is the target rather than as a substitute for systemic delivery