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The simulations suggested that moving from weekly to every 14 days preserved about 70% of weight loss seen with weekly dosing, and even monthly dosing maintained roughly half of the effect

Granted, even with baseline x-rays for comparison purposes, relying upon the x-rays alone and their VHS values only tell the clinician that the heart as a whole is enlarged, and not whether the left atrium (LA) and/or the left ventricle (LV) are enlarged