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Delays can arise from clinical trial results, regulatory review, or production issues

The American Diabetes Association notes that GH excess (as seen in acromegaly) causes frank diabetes in approximately 20-30% of patients [11], a caution that extends by mechanism to prolonged secretagogue use

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Below is an overview of how the two compare: Mechanism of Action: Retatrutide: Triple agonist (GLP-1, GIP, glucagon) Zepbound: Dual agonist (GLP-1, GIP) Developer: Retatrutide: Eli Lilly and Company (investigational) Zepbound: Eli Lilly and Company (approved) Regulatory Status: Retatrutide: Phase III clinical development Zepbound: FDA-approved for obesity, obstructive sleep apnea Weight Loss Efficacy: Retatrutide: Up to ~28.7% (68 weeks