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Fat tissue produces excess estrogen, which can lead to several types of cancer

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Low event numbers, short follow-up, and heterogenicity in how NAION is defined may contribute to inconsistent findings

Epidemiology Incidence [1] Detected in 0.24.5% of autopsies Detected in 0.52.3% of small bowel contrast studies More common in adults 40 years of age [2] Typically detected in the 6th or 7th decade of life [2] No definitive sex predilection [1] [2] Etiology [1] Acquired pseudodiverticula Intestinal dyskinesia or neuromuscular dysfunction leading to localized areas of increased pressure Herniation occurs at points of weakness in the muscularis layer, typically where vasa recta penetrate the bowel wall on the mesenteric border