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Introduction Stroke is a main reason of mortality and disability, there are 80.1 million prevalent cases of stroke around the world ( For a quarter century, thrombolysis has become a standard of care treatment for AIS ( via catheter angiography) ( Glucagon-Like Peptide-1 and Glucagon-Like Peptide-1 Receptors Glucagon-like peptide-1 (GLP-1), a product of the cleavage of proglucagon in L cells of intestinal epithelium, is mainly secreted as GLP-1(7-36) NH2, an amidated 30-amino acid peptide ( Unlike many gastrointestinal peptides previously found to be insulinotropic in healthy humans or in vitro , but without effect in diabetes (43), depending on the species and results from the effects of the enzyme dipeptidylpeptidase-4 (DPP-4) and renal elimination