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1 Tirzepatides dual agonist activity may result in these benefits in humans as well, as evidenced the significant reductions in glycated hemoglobin (HbA1c) levels and body weight in patients with type 2 diabetes mellitus (T2DM) observed in phase 3 clinical trials (such as, SURPASS

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It has also shown promise in its ability to: Improve spinal cord injury recovery Reduce nerve death and demyelination Reduce symptoms of schizophrenia and protect the brain from harmful agents in animal models [13]

Under these conditions, GLP-1(9-36) was without any inhibitory effect (Fig