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Alongside these, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and C-reactive protein (CRP) are significantly influenced by changes in adipose tissue dynamics and play a central role in the development of obesity-related complications

Importantly, the study found that pasteurizedheat-treatedAkkermansia was more effective than live bacteria, suggesting mechanisms may involve bacterial components rather than colonization