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Additional data suggests that high-dose vitamin E supplementation may benefit those diagnosed with nonalcoholic fatty liver disease, but this has been demonstrated to be associated with the development of insulin resistance

Neurotransplantation therapy, relatively intensively studied in Lurcher mice [114, 220,221,222,223,224,225,226], as well as pharmacotherapy showed rather inconsistent or pessimistic results regarding motor improvement [223], with the exception of mesenchymal stem cell grafting in newborn Lurchers reducing Purkinje cell loss [227]