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Its shorter half-life of 13 hours necessitates daily administration but allows for more rapid dose adjustments
Positive outcomes were also observed in studies investigating associations between GLP-1 RAs and prostate cancer (lower risk in meta-analyses), while breast cancer shows no effect
This was interpreted to indicate that the beta cell failure of type 2 diabetes, i.e., the inability of the cells to respond to glucose with appropriately increased insulin secretion also would apply to the incretin hormones [in agreement with the demonstration by Perley and Kipnis (59) of the loss of incretin effects in type 2 diabetes]
(2007) reported that the plasma BDNF levels of patients with T2DM were lower than those of healthy controls, and hyperglycemia could inhibit the output of BDNF from the brain
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