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The Lau monotherapy data cuts through that by showing the amylin analog producing double-digit weight loss entirely on its own, which is the cleanest argument that adding it to a triple agonist brings genuinely additive firepower rather than redundant signalling

Moreover, the relatively small change in NOE intensity observed for the CTAB/SNAC -a/c NOE crosspeak also indicates that aggregation size effects on the correlation times are very likely small compared to the changes in NOEs caused by SNAC aggregation in our system, consistent with the fact that the large CTAB/SNAC aggregates (Fig

PMC 8826179

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