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Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids
The funding source was not involved in the study design, collection, analysis or interpretation of data
doi: 10.1152/ajpendo.00499.2003 151 UrvaSCoskunTLoghinCCuiXBeebeEO'FarrellLet al
It appears to enhance the expression of growth factors like VEGF (vascular endothelial growth factor) , support nitric oxide pathways for improved circulation, and reduce pro-inflammatory markersall without disrupting normal healing responses
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