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Each titration level is maintained for at least 4 weeks to ensure tolerability

Lumping of whole-body physiologically based pharmacokinetic models

Some medicines and grapefruit juice may increase the level of ethinyl estradiol in your blood if used together, including: the pain reliever acetaminophen ascorbic acid (vitamin C) medicines that affect how your liver breaks down other medicines (such as itraconazole, ketoconazole, voriconazole, fluconazole, clarithromycin, erythromycin, and diltiazem) certain HIV medicines (atazanavir/ritonavir and indinavir) non-nucleoside reverse transcriptase inhibitors (such as etravirine) medicines to lower cholesterol such as atorvastatin and rosuvastatin Hormonal birth control methods may interact with lamotrigine, a medicine used for seizures