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In the absence of efficient repair mechanisms, cell membranes in yeast cells are oxidized, the structure and function of proteins are modified, and DNA is damaged [16]

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High-risk features at baseline: Prior symptomatic gallstones or biliary colic Existing asymptomatic stones on prior imaging Obesity (BMI 35), particularly in female patients over 40 Rapid prior weight loss history Crohn's disease or terminal ileal resection (impairs bile salt reabsorption) Family history of cholelithiasis Patients with prior symptomatic gallstones should discuss prophylactic cholecystectomy with a surgeon before starting semaglutide, or at minimum have a baseline ultrasound documented in the chart

Besides, weight-loss drugs can be expensive and aren't always paid for by insurance