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It has been previously reported that in mice AD model, IF has the beneficial effects on anxiety and cognition which is mediated by Sirt3 through increasing the enzymatic activity of SOD [28]

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As a Se transport protein, SELENOP significantly contributes to Se-dependent brain pathways, including: redox signaling, protein folding, neurochemical signal transduction, and cytoskeleton assembly (Loef et al., 2011