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Early clinical studies with Melanotan II unexpectedly identified potent pro-sexual and pro-erectile effects in male volunteers effects mediated centrally through the melanocortin system rather than through peripheral vascular mechanisms which prompted the development of PT-141 as a purpose-designed, more selective CNS melanocortin agonist optimised for sexual behaviour research and clinical application

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Topical pain relief (creams, patches), physical therapy, and ice/heat therapy avoid systemic medication interactions altogether

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