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They may provide incremental benefits when used appropriately and under supervision

Sex-stratified subgroup analyses of epigenetic aging outcomes were not pre-specified and the study was not powered to detect sex-specific effects

The second tier applies to beneficiaries with a BMI of 30 to 34.9 who also have at least one of the following conditions: heart failure with preserved ejection fraction (HFpEF), uncontrolled hypertension (defined as systolic blood pressure above 140 mmHg or diastolic above 90 mmHg despite concurrent treatment with two antihypertensive medications), or chronic kidney disease at stage 3a or higher

Finally, we identify current research gaps and propose future directions toward harnessing AST for promoting cognitive resilience and delaying the progression of neurodegenerative disorders