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Okuno, S., Sato, H., Kuriyama-Matsumura, K., Tamba, M., Wang, H., Sohda, S

(2013) conducted a formal pharmacokinetic study in nine healthy male volunteers, establishing a biphasic profile: a rapid distribution phase of approximately 7.6 minutes followed by an elimination phase of approximately 2.5 hours

10.1016/j.bbr.2020.112923 33

High-Risk Contexts Although GLP-1RA therapy is generally safe and effective, the flux-constraint framework suggests that certain populations may be more sensitive to substrate imbalance during sustained hypophagia