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Functions : The reduced form of folic acid (tetrahydrofolate) acts as a cofactor for many one-carbon transfer reactions in nucleotide synthesis (especially the conversion of dUMP to dTMP in the synthesis of thymidylate), in methionine synthesis (especially the conversion of homocysteine to methionine), and in the conversion of serine to glycine and vice versa

A second protease of this family, proprotein convertase subtilisin/kexin type 6 (PACE4), also exists both intra- and extracellularly

Any interest in research-stage compounds should involve detailed discussion with a qualified healthcare provider

Hayashi K, Anzai N