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[1] [2] It works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

But he noted yet another hormone, glucagon, which is the third addition to Lillys retatrutide, is very good at getting fat out of the liver, so it may be especially helpful for people with metabolic liver disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Fedewa MV, Hathaway ED, Ward-Ritacco CL

This has also been a group that has been relatively the most underrepresented in clinical trials given the share of Hispanics in the total U.S