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Current US guidelines, including those from the US Preventive Services Task Force and American College of Gastroenterology, emphasize that new rectal bleeding in adults 45 and older requires investigation to exclude colorectal malignancy, regardless of presumed benign causes

Additionally, in a phase 2 trial targeting type 2 diabetes, retatrutide demonstrated significant improvements in glycemic control and substantial weight reduction, maintaining a safety profile comparable to certain approved GLP-1RAs 8 (Supplementary Table S1)

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

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