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[9] Onakpoya IJ et al

The growing body of clinical evidence supporting the long-term efficacy and safety of agents such as semaglutide and tirzepatide has strengthened physician confidence and expanded reimbursement coverage in key markets Moreover, the rising interest from younger demographics, increased public awareness through social media, and celebrity endorsements are normalizing the use of obesity drugs, further accelerating consumer demand

In individuals with IBD, proinflammatory cytokines downregulate OCTN2 through the PPAR/RXR pathway, resulting in reduced carnitine uptake by intestinal epithelial cells that leads to the dysfunction of intestinal regeneration and repair and further deterioration of IBD [232]

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