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Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH

Kuckelman, Novos senior vice president and general counsel, said Novo welcomes competition grounded in science, but it cannot stand by as advertising continues to withhold the information patients need, saying Lillys misleading ads leave patients with the mistaken impression that Lilly's drugs are vastly superior, and that is simply not true. In a statement earlier this week, Lilly said it stood by its ads, calling them "truthful," "transparent" and grounded in the most direct scientific evidence available - exactly what patients deserve. What Did Novo Nordisk Allege In Its Lawsuit

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