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On average, they had less total sleep time (326.3 minutes) compared to those without RLS (383.3 minutes), lower sleep efficiency (73.2% versus 86.6%), and more frequent awakenings (12.2 times versus 7.4 times)

Biochem Biophys Res Commun 246(3):589595 Wu G, Nan C, Rollo JC, Huang X, Tian J (2010) Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase

SEV-2017-0706)

For example, the sustained elevation of pro-inflammatory mediators such as interleukin (IL)-6, tumour necrosis factor alpha (TNF-) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), and transforming growth factor beta (TGF)-1 are likely to accelerate liver fibrosis and cause non-alcoholic steatohepatitis (NASH), a severe condition of NAFLD [14,15,16,17]