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Tirzepatide lowers blood sugar, and if you are also taking insulin or a sulfonylurea alongside it, your blood sugar can drop too low (hypoglycemia)

SGLT2 inhibitors have shown stronger evidence for reducing hospitalizations related to heart failure

This is important because HFpEF is a diverse condition with different underlying causes than HFrEF, and therapies effective in HFrEF have not always been successful in HFpEF.8,31,32 While prior reviews may have given importance to conventional endpoints like mortality and HF hospitalization, our study emphasis the significance of symptom burden and functional status, which are crucial for living with HFpEF.33 Prior analyses of GLP-1RAs in HFpEF have yielded insightful information, however, they have some limitations