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Given its demonstrated efficacy in reducing apoptosis in other neurological diseases, this mechanism holds significant application potential in PD, providing a theoretical foundation for hydrogen as a novel neuroprotective agent in the treatment of PD

Based on its molecular size and lipophilic properties, it appears unlikely that Adropin can readily diffuse from the systemic circulation into the CNS [160, 163]

3,15,17,19,24 Transthoracic echocardiography is helpful in evaluating patients for structural heart disease and should be performed when the initial history, physical examination, and ECG findings are unremarkable, or in patients with a history of cardiac disease or more complex signs and symptoms (e.g., dyspnea, rales, elevated jugular venous pressure, orthopnea, lower extremity edema)

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