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Of note, there are two main ways in which environmental chemicals can affect the microbiota: (a) by altering the microbial taxonomy and diversity, and (b) by altering the functional phenotype of the microbiota ( Despite the differences between in vivo and in vitro studies, the bioreactor offers several advantages as a tool for risk assessment of EDCs

These outcome trials aimed to determine cardiovascular safety and thus most of them were designed to show non-inferiority of the drug against placebo

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