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We need better science, not less of it

Take home message Eli Lilly reported on 21 May 2026 that retatrutide produced an average weight loss of up to 30.3% in its Phase 3 TRIUMPH-1 trial, the largest figure reported so far for a weight-loss injection

The approval by the National Institute of Health and Care Excellence (NICE) of Novo Nordisks controversial weight loss drug, Wegovy (semaglutide), in April this year has reignited the debate, bringing issues such as health equity, safety and health economics to the fore

AMINO-1MQ (5-Amino-1MQ) NNMT Inhibitor Research Compound AMINO-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) , an enzyme involved in cellular methylation and NAD+ metabolism