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In brief, first-generation NPs nonspecifically targets tumor cells, second-generation focuses on active targeting through incorporation of ligands and specific antigens at NPs surfaces and third generation provides a multi-stage strategy best matching therapy and diagnostic (theranostic) purposes
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Appl Microbiol Biotechnol 94:13131319 Hara KY, Aoki N, Kobayshi J, Kiriyama K, Nishida K, Araki M, Kondo A (2015) Improvement of oxidized glutathione fermentation by thiol redox metabolism engineering in Saccharomyces cerevisiae
Solid-phase peptide synthesis (SPPS) the workhorse for many GLP-1 APIs generates large volumes of solvent and resin waste
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