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Concurrently, pivotal metabolic enzymes within the amino acid synthesis pathway, including glutamate-oxaloacetate transaminase 1 (GOT1), glutamate-pyruvate transaminase 2 (GPT2), pyrrolidine-5-carboxylic acid reductase 1 (PYCR1), and phosphoserine aminotransferase 1 (PSAT1), demonstrated increased expression [214]

The vitamin C dose was 4 g

The molecular mechanisms by which the disruption of the cell redox state plays a role in the pathogenesis of GO, as well as the potential beneficial effect of other antioxidant agents in patients with GO, are largely discussed in another review article in this issue of the journal

If time of overdose is unknown: Start NAC(N-acetylcysteine) Determine serum acetaminophen levels Determine INR(International Normalized Ratio) levels and LFT Continue treatment with N-acetylcysteine if serum acetaminophen levels detected or transaminases are detected