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Slow titration was the main lever for tolerance

Decreases in body weight, BMI, and waist circumference Improved insulin sensitivity and blood sugar control Reduced total testosterone levels More regular menstrual cycles and higher rates of natural ovulation Theres also evidence that combining GLP-1s with metformin, a long-standing insulin-sensitizing medication, may amplify these benefits, especially for women whove struggled to lose weight on metformin alone

Side effect profiles differ across compounds as well

Health organizations such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) provide clinical guidelines and recommendations