Semaglutide Intermediates: (1) Main Chain : GLP-1 (9-37), CAS No.: 1169630-82-3, 95% up by HPLC (2) Side Chain : tBuO-Ste-Glu(AEEA-AEEA-OH-OtBu CAS No.: 1118767-16-0, 98% up by HPLC Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEAI-OH CAS No.:1662688-20-1 , 98% up by HPLC (3) Molecular Blocks Octadecanedioic Acid Mono-tert-butyl Ester CAS No.: 843666-40-0, 98% up by HPLC AEEA-OH-HQ CAS No.: 134979-01-4, 98% up by HPLC Fmoc-AEEA-OH CAS No.: 166108-71-0, 98% up by HPLC Boc-AEEA-OH CAS No.: 108466-89-3, 98% up by HPLC Fmoc-AEEA-AEEA-OH CAS No.: 560088-89-3, 98% up by HPLC AEEA-AEEA-OH CAS No.: 1143516-05-5, 98% up by HPLC Boc-Hs( Trt)-Aib-OH CAS No.: 2061897-68-3, 99% up by HPLC Fmoc-Glu(OtBu)-Gly-OH CAS No.: 866044-63-5, 99.5% up by HPLC Boc-His(Eoc)-Aib-Glu(OtBu)-Gly-OH CAS No.: 1169630-31-2, 98% up by HPLC Function of Semaglutide Semeglutide is a long-acting glucagon-like peptide 1 (GLP-1) analog, a GLP-1 receptor agonist, and has potential therapeutic efficacy in type II diabetes mellitus (T2DM)
However, some individuals may experience mild side effects such as gastrointestinal discomfort or allergic reactions
In summary, development defects in the CNS in GDH-HI patients could be caused by multiple factors, including chronic hyperammonemia, and hyperinsulinemia, the more detailed mechanisms need to be further studied
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