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Current investigations focus on understanding how coordinated receptor interaction influences pathway activity under controlled experimental conditions

Nowadays, the prevalence of NAFLD and NASH is rising primarily due to the increased incidence of diabetes and MS

Unlike the atmospheric oxygen tension typically encountered in vitro (approximately 21% O 2 ), the oxygen tension in vivo is markedly lower, often decreasing to 3% or even less, especially in injured tissues (Wang et al., 2022), migration (Yang et al., 2019), and angiogenesis (Zhu et al., 2014)

doi:10.1038/s41591-022-02026-4 6 Jastreboff AM et al.: Tirzepatide for Obesity Treatment and Diabetes Prevention