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For instance, the therapeutic benefits of many natural antioxidants were reported to be associated with their effects to modulate gut microbiota (Shen and Ji, 2019

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Second, the medication's adverse effect profileparticularly gastrointestinal symptoms, as well as risks of pancreatitis, gallbladder disease, and hypoglycemia when combined with certain medicationsmay limit tolerability in some patients, potentially affecting treatment retention

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