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The paper employs a mixed-method approach to address the coherence between strategies, policies and results

Lee JS, Jin MH, Lee HJ

89 In addition to ONOO -mediated oxidation of BH 4 , there may be also an intracellular decrease because of decreased synthesis by inhibition of the GTP cyclohydrolase I ( de novo synthetic pathway) or by inhibition of the so-called salvage pathway involving enzymes such as the sepiapterin synthase, the sepiapterin reductase or the dihydrofolate reductase

ORM-6151 (BMS-986497) is currently being clinically evaluated in patients with AML and MDS, while the pre-clinical ORM-1153 may expand Orums presence into additional hematologic malignancies