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Taking these facts into consideration, the Food and Drug Administration (FDA) recommended that in order to establish the safety of a new antidiabetic therapy for T2DM, the manufacturers or sponsors should demonstrate that the new drug will not result in an unacceptable increase in cardiovascular risk and the trials population should also include high risk patients

[7]: Quetiapine (300-600 mg day): Seven out of seven studies positive, N = 2,152, SDM: 0.35 (0.23-0.47), Olanzapine: four RCTs, N = 732 (SDM: 0.35 (0.17-0.54), Lurasidone: Four RCTs, N = 1,029, SDM: 0.29 (0.14-0.45) and Cariprazine: Four RCTs, N = 997, SDM: 0.23 (0.06-0.39)

Retrieved from Verbeeck W, Bekkering GE, Van den Noortgate W, Kramers C

10.1016/0925-4439(94)90082-5 Biochim